|
KMID : 0359920080270040513
|
|
Korean Journal of Nephrology
2008 Volume.27 No. 4 p.513 ~ p.517
|
|
|
Selective Proximal Tubule Injury and Progressive Renal Failure due to Ifosfamide and Cisplatin in a Patient with Ovarian Cancer
|
|
Kim Su-Hyun
Park Eun-Young
Kim Wan-Young
Kim Jin
Kim Young-Soo
Bang Byung-Kee
Nam Sung-Min
Yoon Hye-Eun
Kim Yong-Kyun
Yang Chul-Woo
|
|
|
Abstract
|
|
|
|
Ifosfamide-induced nephrotoxicity is usually manifested in the form of Fanconi syndrome and the combination of cisplatin enhances ifosfamide-induced nephrotoxicity. We here report a case of report specific proximal tubular dysfunction and progressive renal failure after ifosfamide and cisplatin chemotherapy in a 32-year old woman with ovarian cancer. The patient was referred to our department due to severe hypokalemia and elevated serum creatinine. Her renal function was abruptly impaired and serum and urine electrolytes were consistent with Fanconi syndrome. The kidney biopsy revealed atrophy and falling of renal tubular cells, and immunohistochemical staining with aquaporin 1 (AQP1) revealed that injured epithelial cells were proximal tubular cells. This finding suggests that ifosfamide selectively impairs proximal tubule function and combination with cisplatin causes progressive renal failure
|
|
|
KEYWORD
|
|
|
fosfamide, Fanconi syndrome, Renal failure
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|